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Professors

July 3, 2024

Stephanie Leal

Stephanie Leal

Assistant Professor

Email: stephanieleal@ucla.edu
Office: 2802 LSB
Phone:
Website: http://memory.ibp.ucla.edu/

Biography

Dr. Stephanie Leal is an Assistant Professor in the Department of Integrative Biology & Physiology at UCLA, Adjunct Assistant Professor at Rice University, and Director of the Neuroscience of Memory, Mood, & Aging Laboratory. She received her B.S. in Biopsychology from the University of California, Santa Barbara in 2011 and her Ph.D. in Psychological & Brain Sciences from Johns Hopkins University in 2016 working in the lab of Dr. Michael Yassa. She completed an NIH-funded NRSA postdoctoral fellowship from 2016-2019 at the University of California, Berkeley with Dr. William Jagust. Dr. Leal started her laboratory at Rice University in 2019 and recently joined the faculty at UCLA in 2024.

Research Interests

Dr. Leal’s research interests focus on the neurobiological mechanisms underlying episodic memory processing, emotional modulation of memory, and how these mechanisms are altered in aging and disease states. She develops and utilizes sensitive cognitive tasks, advanced neuroimaging techniques, and translates these methods to states of cognitive impairment. Her overarching goal is to understand the factors that modulate episodic memory processing in order to restore the system to normal function in disorders of mood and memory.

Education

2011 – 2016, Ph.D., Psychological & Brain Sciences, Johns Hopkins University, Baltimore, MD
2011 – 2013, M.A., Psychological & Brain Sciences, Johns Hopkins University, Baltimore, MD
2007 – 2011, B.S., Biopsychology, University of California, Santa Barbara, CA

Selected Publications

Phillips, T.*, Castro, M.**, Vas, R.*, Ferguson, L. A.**, Harikumar, A., & Leal, S. L. (2023). Perceived antidepressant efficacy associated with reduced negative and enhanced neutral mnemonic discrimination. Frontiers in Human Neuroscience, 17:1225836.

Ferguson, L.A.** & Leal, S.L. (2022). Interactions of Emotion and Memory in the Aging Brain: Neural and Psychological Correlates. Curr Behav Neurosci Rep. 9, 47-57.

Leal. S.L., Landau, S.M., Bell, R.K., & Jagust, W.J. (2017). Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline. eLife, 6:e22978.

Leal, S.L. & Yassa, M.Y. (2018). Integrating new findings and examining clinical applications of pattern separation. Nature Neuroscience, 21(2):163-173.

Leal, S.L., Tighe, S.K., Jones, Craig K., Yassa, M.A. (2014). Pattern separation of emotional information in hippocampal dentate/CA3. Hippocampus. 24: 1146-1155.

Press and Media

July 3, 2024

Beau Alward

Beau Alward

Assistant Professor

Email: balward@ucla.edu
Office: 1159 TLSB
Phone:

Biography

Beau Alward got his associates degree at American River Community College before transferring to the University of California, Davis where he earned a BS in Neurobiology, Physiology, and Behavior. After graduating, he worked as a behavioral therapist for children with Autism for a year and half before starting his PhD with Gregory Ball at Johns Hopkins University. His dissertation work was on the neuroendocrine regulation of birdsong in canaries. Beau did his postdoctoral research on the hormonal control of social dominance in cichlids in Russell Fernald’s lab at Stanford University, where he was an Arnold Beckman Postdoctoral Fellow. Research in his lab aims to understand how steroid hormones modulate social behaviors in the cichlid fish Astatotilapia burtoni.

Research Interests

The Alward lab is interested in how steroid hormones generate social behaviors. Our chosen organism for answering this question is the cichlid fish Astatotilapia burtoni. These fish exhibit dynamic social interactions that can be readily studied in the lab. We combine approaches using molecular genetics, transcriptomics, neurobiology, and behavioral paradigms in both sexes to yield fundamental insights into the hormonal control of behavior.

Education

2011 – 2015, Ph.D., Psychological & Brain Sciences, Johns Hopkins University, Baltimore, MD
Advisor: Gregory Ball, Ph.D.
Dissertation: “Anatomical specificity of the action of testosterone in relation to the regulation of birdsong and the underlying neuroplasticity”

2011 – 2013, M.A., Psychological & Brain Sciences, Johns Hopkins University, Baltimore, MD

2007 – 2009, B.S., Neurobiology, Physiology, and Behavior, University of California, Davis, CA
Advisor: Thomas Hahn, Ph.D.

2005 – 2007, A.A. Biology, American River Community College, Sacramento, CA

Selected Publications

  1. Dussenne, M., Alward, B. A. (2024). Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain. Journal of Neuroendocrinology, e13429.
  2. Jackson, L.R., Alward, B. A. (2024). Sexually dimorphic control of aggression by androgen signaling in a cichlid. Molecular and Cellular Endocrinology, 592,
  3. Howard, M., Ramsaroop, M., Hoadley, A., Jackson, L.R., Lopez, M.S, Saenz, L., & Alward, B. A. (2024). Female cichlids mate with novel androgen receptor mutant males that lack coloration. Hormones and Behavior, 163,
  4. Lopez, M.S., Alward, B.A. (2024) Androgen receptor alpha regulates aromatase expression in the ventromedial hypothalamus of male cichlids. Annals of the New York Academy of Sciences, 1532, 73-82.
  5. Alward, B.A., Hoadley, A.P., Jackson, L.R., Lopez, M.S. (2023) Genetic dissection of steroid-hormone modulated social behavior: novel paralogous genes are a boon for discovery. Hormones and Behavior, 147,
  6. Alward, B.A., Laud, V.A., Skalnik, C.J., York, R.A., Juntti, S.A., Fernald, R.D. (2020).  Modular genetic control of social status in a cichlid fish. Proceedings of the National Academy of Sciences, 17, 28167-28174.

July 3, 2024

Valerie Tornini

Valerie Tornini

Assistant Professor

Email: vtornini@ibp.ucla.edu
Office: 4365A LSB
Phone:
Website: https://www.torninilab.org/

Biography

I was born and raised in Port Chester, NY, and received my B.S. in biology and A.B. in religion from Duke University. I completed my doctoral training in developmental and stem cell biology and earned my PhD from Duke University, where I investigated how cells in a complex adult tissue coordinately regenerate a patterned structure after injury, primarily using the adult zebrafish fin as a model. I next did my postdoctoral training in the Department of Genetics at Yale School of Medicine, this time using embryonic and larval zebrafish (more info below). Integral to my scientific contributions and philosophies are mentoring, multilingual community engagement, and efforts that prioritize diversity, equity, and inclusion in science. Beyond my professional commitments, I enjoy traveling, playing volleyball and tennis, and spending time in nature with her dog. I am thrilled to start my faculty career through UCLA’s Hispanic Serving Institution (HSI) Infrastructure Initiative in the Department of Integrative Biology and Physiology and the Institute for Society and Genetics.

Research Interests

Dr. Valerie Tornini is a developmental biologist who investigates the cellular and molecular mechanisms of cell specification and specialization in development, particularly of the brain. Her work focuses on understanding the evolving roles of chromatin regulators (including those implicated in autism) and of micropeptides (or sORF-encoded proteins) in vertebrate development. By using zebrafish and other comparative animal models, she is taking candidate and discovery approaches to investigate the gene regulatory networks that establish the cellular diversity of the developing brain. This includes the application of genome engineering, single-cell technologies, behavioral analyses, and pharmacological approaches. Her lab’s current work spans multiple areas, including identifying roles for novel micropeptides in neurodevelopment; chromatin regulators in vertebrate development and behavior; non-neuronal regulation during development and aging; the evolution of vertebrate brain cell states; and bioethics, neuroethics, and genetics.

Education

BS, Biology, Duke University
AB, Religion, Duke University
PhD, Cell Biology, Duke University
Postdoctoral Fellowship, Department of Genetics, Yale School of Medicine

August 16, 2023

Duncan Leitch

Duncan Leitch

Assistant Professor

Duncan Leitch

Email: dleitch@ucla.edu
Office: LSB 4835
Phone:
Website: https://leitch.ibp.ucla.edu/

Biography

Dr. Duncan Leitch grew up in Memphis, TN. He completed undergraduate degrees in mathematics and neuroscience, followed by a PhD in systems neuroscience with Dr. Kenneth Catania (Vanderbilt University, Nashville, TN, US). His doctoral thesis focused on comparative mechanosensory neurophysiology with a particular focus on novel sensory organs in diverse vertebrates. Following grad school, he was a postdoctoral fellow at the University of California – San Francisco with Dr. David Julius, where he studied the molecular basis of the unusual sense of electroreception in elasmobranch fishes. He and colleagues identified novel mutations in voltage-gated calcium and sodium channels that mediated neural responses to low threshold electrical fields using physiological, genetic, and behaviourally analyses. His lab studies diverse sensory adaptations in vertebrates, using transcriptomic, physiological, and behavioural approaches to identify mechanisms of nervous system adaptation. These novel projects include looking at sensory system organization in diverse reptile, amphibian, and fish taxa.

Education

B.S., Mathematics, Vanderbilt University, 2006
B.S., Neuroscience, Vanderbilt University, 2006
Ph.D., Neuroscience, Vanderbilt University, 2013
Post-doctoral fellowship, UC San Francisco, 2019

Selected Publications

Leitch, D.B. and A. Gaede (2021). Specialized somatosensory systems revealed: comparative structure, function, and transduction through cutaneous receptors of the body. In J. Kaas (Ed.), The Senses: A Comprehensive Reference. Elsevier Oxford.

Leitch, D.B.  and D. Julius (2019). Electrosensory transduction: comparisons across structure, afferent response properties, and cellular physiology. In B.A. Carlson and J. Sisneros (Eds.), Electroreception: Fundamental Insights from Comparative Approaches. Springer New York.

Bellono, N*, Leitch, D.B*., Julius, D.J., “Molecular tuning of electroreception in sharks and skates”,  Nature, 558:122-126, 2018. Cover article.

Bellono, N*, Leitch, D.B*., Julius, D.J., “Molecular basis of ancestral vertebrate electroreception”,  Nature, 543:391-396, 2017.

Leitch, D.B. and K.C. Catania. “Structure, innervation, and response properties of integumentary sensory organs in crocodilians”, J Exp Biol, 215, 4217-4230, 2012. Cover article. 

Catania, K.C., Leitch, D.B., Gauthier, D. “Function of the appendages in tentacle snakes (Erpeton tentaculatus)”, J Exp Biol, 213, 359-67, 2010. Cover article.

June 29, 2022

Kacie Deters

Kacie Deters

Assistant Professor

Email: kdeters@g.ucla.edu
Office: 1014 TLSB
Phone:
Website: https://deterslab.ibp.ucla.edu/

Biography

Dr. Kacie Deters earned her B.S. in Biology from the University of Alabama, Birmingham. She had little research experience and was curious if this was the path she wanted to pursue. After a year of figuring out what would make her happy, she ultimately completed her M.S. in Biology from CSU Dominguez Hills in 2012. Science turned into a passion Kacie wanted to explore more. In 2017, she earned her Ph.D. in Medical Neuroscience at the Indiana University School of Medicine focusing on genetic and imaging characteristics of tauopathies, including Alzheimer’s disease. Kacie then completed her first postdoc in 2021 at Stanford University with Dr. Elizabeth Mormino where she first began to explore ethnic and racial disparities existed in AD biomarkers. COVID hit, and Kacie decided to take a second postdoc, which she completed in 2022 at the University of California, San Diego in the Department of Neurosciences with Dr. Sarah Banks. While at UCSD, Kacie expanded her training to understand racial bias that exists in neuropsychological assessments. While at UCLA, Kacie’s lab will focus is on ethnic and racial disparities in predictors (genetic; neuroimaging; neuropsychological assessments; social/environmental factors) for cognitive decline and Alzheimer’s disease and related dementias in older adults, primarily from the Black community.

Research Interests

Although Black communities are plagued by health disparities, science has continued to center white populations in research. While research into ethnic and racial disparities studies has identified a number of population differences for disease risk factors, it is also important to understand within group heterogeneity in order to elucidate mechanisms underlying cognitive decline. Understanding the intersection of risk factors that drive cognitive decline and dementia in the Black population is critical to accurately assess, predict, and develop interventions for cognitive health. Thus, my goal is understanding the intersection and contributions of genetics and social/environmental factors to cognitive decline and AD. Research will utilize a number of techniques including genetic, neuroimaging, neuropsychological assessments, social and environmental factors, and fluid based biomarkers.

Education

B.S., Biology, University of Alabama, Birmingham 2008
M.S., Biology, California State University, Dominguez Hills 2012
Ph.D., Medical Neuroscience at the Indiana University School of Medicine 2017

Selected Publications

Deters KD, Napolioni V, Sperling RA, Greicius MD, Mayeux R, Hohman T, and Mormino EC. Amyloid PET imaging in self-identified non-Hispanic Blacks from the Anti-Amyloid in Asymptomatic Alzheimer’s Disease (A4) Study. Neurology. 2021. DOI: 10.1212/WNL.0000000000011599. Highlighted with an editorial.

Deters KD, Mormino EC, Yu L, Lutz M, Bennett DA, and Barnes LL. TOMM40-APOE haplotypes are associated with cognitive decline in non-demented Blacks. Alzheimer’s & Dementia. 2021. https://doi.org/10.1002/alz.12295

Avila JF, Rentería MA, Jones RN, Vonk JM, Turney I, Sol K, Nika Seblova N, Arias F, Hill-Jarrett T, Levy SA, Meyer O, Racine AM, Tom SE, Melrose RJ, Deters K, Medina LD, Carrión CI, Díaz-Santos M, Byrd DR, Chesebro A, Colon J, Igwe KC, Maas B, Brickman AM, Schupf N, Mayeux R, and Jennifer Manly J. Education Differentially Contributes to Cognitive Reserve Across Racial/Ethnic Groups. Alzheimer’s & Dementia. 2020. https://doi.org/10.1002/alz.12176

Winer JR, Deters KD, Kennedy G, Jin M, Goldstein-Piekarski A, Poston KL, Mormino EC. Short and long sleep duration are associated with distinct aging pathways. JAMA Neurol. 2021 Aug 30; doi: 10.1001/jamaneurol.2021.2876.

October 2, 2020

Pearl Quijada

Pearl Quijada

Assistant Professor

Email: pquijada@ucla.edu
Office: 1013D TLSB
Phone: (310) 825-2099

Biography

Pearl received her BS in Biology from UC Riverside. To further explore interests in research and medicine, she pursued a Master’s degree in Cell and Molecular Biology at San Diego State University (SDSU) where she also served as a Human Anatomy Teaching Assistant for 3 years. At SDSU, she gained research technical expertise in cardiac pathophysiology and the development of cellular therapies to treat cardiac ischemic injury in the lab of Dr. Mark Sussman. After receiving her PhD from SDSU and UCSD, she began a postdoctoral fellowship under the mentorship of Dr. Eric Small at the University of Rochester where she studied novel mechanisms of epicardium-directed coronary vasculature formation during cardiac development and disease. Continuing her passion for teaching, she was awarded an Outstanding Postdoctoral Mentor Award during her postgraduate training. Transitioning to UCLA and returning to her family, community, and home in Los Angeles – her research lab will focus on evaluating novel cellular and paracrine signaling programs that stimulate angiogenesis in cardiac development, discoveries which may be used to promote cardiac remodeling and repair in the heart after myocardial infarction.

Research Interests

The epicardium is composed of a single cell layer that encapsulates the heart during embryogenesis. The epicardium also serves as a rich source of mesenchymal cells and growth factors that support both cardiomyocyte and coronary vasculature development. Although the function of the epicardium is invariably linked to the growth of the primitive coronary plexus, the cellular and molecular mechanisms that regulate cell autonomous and cell non-autonomous functions of the epicardium remain unclear. To facilitate the identification of the epicardium’s role in embryonic angiogenesis, our lab utilizes transgenic mouse models and single-cell transcriptomic sequencing to discover novel epicardium-directed guidance cues required for arterio-venous specification and maturation. As compared to the fetal heart, the adult myocardium is unable to undergo angiogenesis in response to ischemic injury, which ultimately leads to cardiac functional decline. By using information acquired from our studies during development, we are investigating the effects of secreted factors from the epicardium to promote angiogenesis and repair after ischemic injury in the adult heart.

Education

B.S., University of California, Riverside 2006
M.S., San Diego State University 2010
Ph.D., San Diego State University and University of California, San Diego 2015

Selected Publications

Quijada, P., Trembley, M.A., Small, E.M. The Role of Epicardium During Heart Development and Repair. Circ Res. Jan 31;126(3):377-394 (2020).

 

Quijada, P., Misra, A., Velasquez, L.S., Burke, R.M., Lighthouse, J.K., Mickelsen, D.M., Dirkx, R.A. Jr., Small, E.M. Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging. J Mol Cell Cardiol. 129:92-104 (2019).

 

Quijada, P., Salunga, H.T., Hariharan, N., Cubillo, J., El-Sayed, F., Moshref, M., Bala, K.M., Emathinger, J., De La Torre, A., Ormachea, L., Alvarez, R., Gude, N.A., Sussman, M.A. (2015) Cardiac stem cell hybrids enhance myocardial repair. Circ Res. 117(8):695-706 (2015).

 

Quijada, P., Hariharan, N., Cubillo,J., Bala, K.M., Ormachea, L., Bers, D.M., Sussman, M.A., Poizat, C. Nuclear Calcium/Calmodulin-Dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment. J Biol Chem. 290(42):25411-26 (2015).

 

Quijada, P., Toko, H., Fischer, K.M., Bailey, B., Reilly, P., Hunt, K.D., Gude, N.A., Avitabile, D., Sussman, M.A. Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells. Circ Res. 111(1):77-86 (2012).

April 23, 2020

Stephanie Correa

Stephanie Correa

Associate Professor
Vice Chair of Undergraduate Education

Email: stephaniecorrea@ucla.edu
Office: 2028 TLSB
Phone: (310) 825-1559
Website: http://www.correalab.org/

Biography

Stephanie Correa earned a BA in Biology from Pomona College and a PhD in Neurobiology and Behavior from Cornell University. Her dissertation research with Elizabeth Adkins-Regan and Patricia Johnson tested the effects of ovarian steroids on sex determination in birds. Her postdoctoral research at Boston University Medical Center identified strain differences in the testis determination pathway in mice. Postdoctoral research with Holly Ingraham at UCSF identified neurons in the hypothalamus that regulate physical activity and body weight in female mice. Research in her lab aims to understand sex differences in the regulation of temperature and energy balance. Before having twin daughters in 2016, Dr. Correa used to enjoy yoga and sleep.

Research Interests

The Correa lab is broadly interested in understanding how reproductive hormones affect temperature and energy balance. In women, the menopausal transition is associated with hot flashes and increased visceral body fat. Our research aims to understand how estrogens act on the hypothalamus to alter temperature homeostasis and metabolic health. These studies can help us better understand weight gain and hot flashes in postmenopausal women. To understand the mechanisms by which estrogen alters the homeostasis, we focus on the following broad questions: How does the brain regulate temperature and energy balance? How do homeostatic neural circuits differ between males and females? How are homeostatic circuits modulated by estrogens? We use genetically engineered mice and new viral tools to define the neurons that drive estrogen-responsive and sex-specific changes in energy balance. This approach allows us to dissect the effects of estrogen on distinct neuronal populations with spatial, molecular, and temporal specificity. Ultimately, we hope to identify avenues for developing targeted, non-hormonal treatments for hot flashes and obesity.

Education

B.A., Biology, Pomona College 2000
Ph.D., Neurobiology and Behavior, Cornell University 2007

Selected Publications

van Veen, J. E.*, Kammel, L. G.*, Bunda, P. C., Shum, M., Reid, M. S., Massa, M. G., Arneson, D. V., Park, J. W., Zhang, Z., Joseph, A. M., Hrncir, H., Liesa, M., Arnold, A. P., Yang, X., and Correa, S. M. Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure. Nature Metabolism, 2: 351–363 (2020).

Kammel, L. G. and Correa, S. M. Selective sexual differentiation of neuron populations may contribute to sex-specific outputs of the ventromedial hypothalamus. Journal of Neuroendocrinology, 32: e12801 (2020).

Herber C. B.*, Krause, W. C.*, Wang, L., Bayrer, J. R., Li, A., Schmitz, M., Fields, A., Ford, B., Zhang, Z., Reid, M. S., Nomura, D. K., Nissenson, R. A., Correa S. M.#, and Ingraham, H. A.# Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nature Communications, 10: 163 (2019).

Correa, S. M., Newstrom, D. W., Warne J. P., Flandin, P., Cheung, C. C., Pierce, A. A., Lin-Moore, A. T., Xu, A. W., Rubenstein, J. L. and H. A. Ingraham, An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females, Cell Reports, 10 : 62-74 (2015).

Correa, S. M., Washburn, L. L., Kahlon, R. S., Musson, M. C., Bouma, G. J., Eicher, E. M. and Albrecht, K. H., Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway, PLoS Genetics, 8 (4): 1002569-1002588 (2012).

Correa, S. M.#, Horan, C. M., Johnson, P. A., Adkins-Regan, E., Copulatory Behaviors and Body Condition Predict Post-Mating Female Hormone Levels, Fertilization Success, and Primary Sex Ratios in Japanese Quail, Hormones and Behavior, 59 : 556-564 (2011).

Correa, S. M.#, Adkins-Regan, E., and Johnson, P. A., High Progesterone During Avian Meiosis Biases Sex Ratios Toward Females, Biology Letters, 1 : 215-218 (2005).

 

December 13, 2019

Roy Wollman

Roy Wollman

Professor

Roy Wollman

Email: rwollman@ucla.edu
Office: 540 Boyer Hall
Phone: (855) 810-0905
Website: wollmanlab.ucla.edu

Biography

Dr. Wollman’s training was highly interdisciplinary including statistics, biophysics, experimental biology. He is passionate about science, mentoring, and kite flying.

Research Interests

The Wollman lab studies information processing in intracellular and intercellular signaling networks in the presence of a high degree of single-cell variability. A particular focus is on the connection between gene expression and signaling dynamics at the single cell level.

Education

B.Sc, Biology, Tel Aviv University 2003
B.Sc, Statistics And Operation Research, Tel Aviv University 2003
Ph.D., Cell and Developmental Biology, University of California, Davis 2008

Selected Publications

Zhang T, Pilko A, Wollman R (2020) ‘Loci specific epigenetic drug sensitivity.’ Nucleic Acids Res, doi: 10.1093/nar/gkaa210 .PMID: 32246716 Foreman R, Wollman R (2020) ‘Mammalian gene expression variability is explained by underlying cell state.’ Mol Syst Biol, 16 (2): e9146. PMID: 32043799 Handly LN, Wollman R, “Wound-induced Ca2+ wave propagates through a simple release and diffusion mechanism”, Molecular Biology of the Cell, 28 (11): 1457-1466 (2017) . Yao J, Pilko A, Wollman R., “Distinct cellular states determine calcium signaling response”, Molecular Systems Biology, 12 (12): 894-904 (2016) . Handly LN, Pilko A, Wollman R (2015) ‘Paracrine communication maximizes cellular response fidelity in wound signaling.’ Elife, 4 (): e09652. PMID: 26448485 Selimkhanov J, Taylor B, Yao J, Pilko A, Albeck J, Hoffmann A, Tsimring L, Wollman R (2014) ‘Accurate information transmission through dynamic biochemical signaling networks.’ Science, 346 (6215): 1370-3. PMID: 25504722

 

December 13, 2019

Xinshu Grace Xiao

Xinshu Grace Xiao

Professor
Director of Bioinformatics Interdepartmental Ph.D. Program
Maria Rowena Endowed Chair in Biological Sciences

Email: gxxiao@ucla.edu
Office: 2000E TLSB
Phone: (310) 206-6522
Website: https://www.xiao-lab.org/

Biography

Dr. Xinshu (Grace) Xiao received her B.S. degree at Tsinghua University, Beijing, China. She then went to the Massachusetts Institute of Technology (MIT) for graduate studies. After receiving her Ph.D degree in the Division of Health Sciences and Technology (HST), a joint program by MIT and Harvard Medical School, Dr. Xiao continued at MIT for postdoctoral training in the Department of Biology. ​In 2008, Dr. Xiao joined the faculty at the University of California, Los Angeles. She is now the Maria R. Ross Endowed Professor of the Department of Integrative Biology and Physiology. She also serves as the Director of the Bioinformatics Interdepartmental Program.

Research Interests

Research in the Xiao lab aims to better understand transcriptome complexity in health and disease. A major surprise resulted from the Human Genome Project was that humans, even though as an apparently much complex organism with 100 trillion cells, have only 25,000 to 30,000 genes. In contrast, the roundworm, an organism with 960 cells, has ~19,000 genes. The number of genes does not scale proportionally with biological sophistication. Instead, the transcriptome (the collection of RNA molecules expressed from genes) in higher organisms is closely regulated such that one gene may produce different transcript isoforms in a cell type and developmental stage-specific manner. The Xiao lab studies transcriptome complexity focusing on RNA splicing, RNA modification and other post-transcriptional mechanisms. With both a computational (dry) lab and an experimental (wet) lab, they develop new bioinformatic methods and experimental systems to understand the regulation and function of transcriptome complexity, and apply these methods to neuropsychiatric disorders and cancer. The lab makes extensive use of second and third generation sequencing technologies in bulk tissues and single cells to drive methodology developments and biological discoveries.

Education

B.S., Tsingua University 1998
M.S., Biomedical/Mechanical Engineering, Massachusetts Institute of Technology 2000
Ph.D., Biomedical Engineering, Massachusetts Institute of Technology, Harvard Medical School 2004

Selected Publications

Tran SS, Zhou Q, Xiao X. Statistical inference of differential RNA-editing sites from RNA-sequencing data by hierarchical modeling. Bioinformatics, 36(9):2796-2804 (2020).

Cass AA, Xiao X. mountainClimber identifies alternative transcription start and polyadenylation sites in RNA-seq.  Cell Systems, 9(4):393-400 (2019).

Tran SS, Jun HI, Bahn JH, Azghadi A, Ramaswami G, Van Nostrand EL, Nguyen TB, Hsiao YE, Lee C, Pratt GA, Martínez-Cerdeño V, Hagerman RJ, Yeo GW, Geschwind DH, Xiao X., “Widespread RNA editing dysregulation in brains from autistic individuals”, Nature Neuroscience, 22 (1): 25-36 (2019) .

Arefeen A, Xiao X, Jiang T., “DeepPASTA: deep neural network based polyadenylation site analysis”, Bioinformatics, 1-9 (2019) .

The Extracellular RNA Communication Consortium, “Establishing Foundational Knowledge and Technologies for Extracellular RNA Research”, Cell, 177 (2): 231-242 (2019) .

Yang EW, Bahn JH, Hsiao EY, Tan BX, Sun Y, Fu T, Zhou B, Van Nostrand EL, Pratt GA, Freese P, Wei X, Quinones-Valdez G, Urban AE, Graveley BR, Burge CB, Yeo GW, Xiao X.Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA., “Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA”, Nature Communications, 10 (1): 1-15 (2019) .

Quinones-Valdez G, Tran SS, Jun HI, Bahn JH, Yang EW, Zhan L, Brümmer  A, Wei X, Van Nostrand EL, Pratt GA, Yeo GW, Graveley BR, Xiao X., “Regulation of RNA editing by RNA-binding proteins in human cells”, Communications Biology, 2 (19): 1-14 (2019) .

Cheung R, Insigne KD, Yao D, Burghard CP, Wang J, Hsiao YE, Jones EM, Goodman DB, Xiao X, Kosuri S., “A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions”, Molecular Cell, 73 (1): 183-194 (2019) .

Hsiao YE, Bahn JH, Yang Y, Lin X, Tran S, Yang EW, Quinones-Valdez G, Xiao X., “RNA editing in nascent RNA affects pre-mRNA splicing”, Genome Research, 28 (6): 812-823 (2018) .

Burkett ZD, Day NF, Kimball TH, Aamodt CM, Heston JB, Hilliard AT, Xiao X, White SA, “FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch”, eLife, 23 (7): 1-35 (2018) .

December 13, 2019

Xia Yang

Xia Yang

Professor
Vice Chair, Molecular, Cellular and Integrative Physiology (MCIP) Interdepartmental Ph.D. Program and Computational and Systems Biology (CaSB) Interdepartmental Program

Email: xyang123@ucla.edu
Office: 2000C TLSB
Phone: (310) 206-1812
Website: https://yanglab.ibp.ucla.edu

Biography

Dr. Xia Yang received her Ph.D. in Molecular Genetics and Bioinformatics from Georgia State University and had postdoctoral training in Systems Genetics at UCLA. She was Senior Research Scientist at Rosetta Inpharmatics/Merck & Co. and Director of Systems Biology at Sage Bionetworks prior to returning to UCLA as a faculty member.

Research Interests

Our research focuses on developing and applying multitissue multiomics systems biology approaches to dissect the molecular networks underlying diverse complex diseases, ranging from cardiometabolic diseases to neurodegenerative and neurological disorders, and utilize the systems level networks to guide precision medicine. Through integration of genetic, transcriptional, epigenomic, proteomic, gut microbiota, and phenotypic data from human and rodent populations, we investigate how complex interactions between genetic and environmental risk factors perturb tissue- and cell-specific gene networks which in turn induce variations in disease susceptibility. Subsequently, we use the causal molecular networks of diseases as the basis for therapeutic target identification and biomarker discovery.

Education

B.S., Pharmacy, Shandong University 1993
Ph.D., Molecular Genetics/Bioinformatics, Georgia State University 2003

Selected Publications

Yang X. “Multi-tissue Multi-omics Systems Biology to Dissect Complex Diseases”. Trends in Molecular Medicine, 2020.

Liu W, Venugopal S, Majid S, Ahn IS, Diamante G, Hong J, Yang X*, Chandler SH*. “Single-cell RNA-seq Analysis of the Brainstem of Mutant SOD1 mice Reveals Perturbed Cell Types and Pathways of Amyotrophic Lateral Sclerosis”. Neurobiology of Disease, 141: 104877, 2020.

Rajbhandari P+, Arneson D+, Feng AC, Ahn IS, Diamante G, Zaghari N, Thomas BJ, Vergnes L, Lee SD, Reue K, Smale ST, Yang X, Tontonoz P. “Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes”. eLife 8:e49501, 2019.

Zhang G, Byun HR, Ying Z, Blencowe M, Zhao Y, Hong J, Shu L, Gomez-Pinilla F, Yang X. “Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice”. BBA – Molecular Basis of Disease. 1866: 165569, 2020.

Shu L, Meng Q, Tsai B, Diamante G, Chen Y, Mikhail A, Luk H, Ritz B, Allard P, Yang X, “Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic Disorders”, Endocrinology, 160 : 409-429, 2019.

Arneson D, Zhuang Y, Byun HR, Ahn IS, Ying Z, Zhang G, Gomez-Pinilla F, Yang X, “Single Cell Molecular Alterations Reveal Pathogenesis and Targets of Concussive Brain Injury”, Nature Communications, 9 : 3894, 2018.

Emilsson V, llkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Jennings LL, Horman SR, Aspelund T, Shu L, Trifonov V, Gudmundsdottir V, Sigurdsson S, Manolescu A, Zhu J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Smith AV, Orth AP, Gudnason V, “Coregulatory Networks of Human Serum Proteins Link Genetics to Disease”, Science, 361 : 769-773, 2018.

Kurt Z, Barrere-Cain R, LaGuardia J, Mehrabian JM, Pan C, Hui ST, Norheim F, Zhou Z, Hasin Y, Lusis AJ, Yang X, “Tissue-specific Pathways and Networks Underlying Sexual Dimorphism in Non-Alcoholic Fatty Liver Disease”, Biology of Sex Differences, 9 : 46- (2018) .

Krishnan KC, Kurt Z, Barrere-Cain R, Sabir S, Das A, Floyd R, Vergnes L, Zhao Y, Che N, Charugundla S, Qi H, Zhou Z, Meng Y, Pan C, Seldin MM, Norheim F, Hui S, Reue K, Lusis, AJ, Yang X., “Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease”, Cell Systems, 6 : 1-13, 2018.

Shu L, Chen KHK, Zhang G, Huan T, Kurt Z, Zhao Y, Codoni V, Tregouet DA, Yang J, Wilson JG, Luo X, Levy D, Lusis AJ, Liu S, Yang X, “Shared Genetic Regulatory Networks for Cardiovascular Disease and Type 2 Diabetes in Multi-ethnic Populations”, PLOS Genetics, 13 (9): e1007040, 2017.