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Integrative Biology and Physiology

Professors

August 16, 2023

Duncan Leitch

Duncan Leitch

Assistant Professor

Duncan Leitch

Email: dleitch@ucla.edu
Office: LSB 4835
Phone:

Biography

Dr. Duncan Leitch grew up in Memphis, TN. He completed undergraduate degrees in mathematics and neuroscience, followed by a PhD in systems neuroscience with Dr. Kenneth Catania (Vanderbilt University, Nashville, TN, US). His doctoral thesis focused on comparative mechanosensory neurophysiology with a particular focus on novel sensory organs in diverse vertebrates. Following grad school, he was a postdoctoral fellow at the University of California – San Francisco with Dr. David Julius, where he studied the molecular basis of the unusual sense of electroreception in elasmobranch fishes. He and colleagues identified novel mutations in voltage-gated calcium and sodium channels that mediated neural responses to low threshold electrical fields using physiological, genetic, and behaviourally analyses. His lab studies diverse sensory adaptations in vertebrates, using transcriptomic, physiological, and behavioural approaches to identify mechanisms of nervous system adaptation. These novel projects include looking at sensory system organization in diverse reptile, amphibian, and fish taxa.

Education

B.S., Mathematics, Vanderbilt University, 2006
B.S., Neuroscience, Vanderbilt University, 2006
Ph.D., Neuroscience, Vanderbilt University, 2013
Post-doctoral fellowship, UC San Francisco, 2019

Selected Publications

Leitch, D.B. and A. Gaede (2021). Specialized somatosensory systems revealed: comparative structure, function, and transduction through cutaneous receptors of the body. In J. Kaas (Ed.), The Senses: A Comprehensive Reference. Elsevier Oxford.

Leitch, D.B.  and D. Julius (2019). Electrosensory transduction: comparisons across structure, afferent response properties, and cellular physiology. In B.A. Carlson and J. Sisneros (Eds.), Electroreception: Fundamental Insights from Comparative Approaches. Springer New York.

Bellono, N*, Leitch, D.B*., Julius, D.J., “Molecular tuning of electroreception in sharks and skates”,  Nature, 558:122-126, 2018. Cover article.

Bellono, N*, Leitch, D.B*., Julius, D.J., “Molecular basis of ancestral vertebrate electroreception”,  Nature, 543:391-396, 2017.

Leitch, D.B. and K.C. Catania. “Structure, innervation, and response properties of integumentary sensory organs in crocodilians”, J Exp Biol, 215, 4217-4230, 2012. Cover article. 

Catania, K.C., Leitch, D.B., Gauthier, D. “Function of the appendages in tentacle snakes (Erpeton tentaculatus)”, J Exp Biol, 213, 359-67, 2010. Cover article.

June 29, 2022

Kacie Deters

Kacie Deters

Assistant Professor

Email: kdeters@g.ucla.edu
Office: 1014 TLSB
Phone:
Website: https://deterslab.ibp.ucla.edu/

Biography

Dr. Kacie Deters earned her B.S. in Biology from the University of Alabama, Birmingham. She had little research experience and was curious if this was the path she wanted to pursue. After a year of figuring out what would make her happy, she ultimately completed her M.S. in Biology from CSU Dominguez Hills in 2012. Science turned into a passion Kacie wanted to explore more. In 2017, she earned her Ph.D. in Medical Neuroscience at the Indiana University School of Medicine focusing on genetic and imaging characteristics of tauopathies, including Alzheimer’s disease. Kacie then completed her first postdoc in 2021 at Stanford University with Dr. Elizabeth Mormino where she first began to explore ethnic and racial disparities existed in AD biomarkers. COVID hit, and Kacie decided to take a second postdoc, which she completed in 2022 at the University of California, San Diego in the Department of Neurosciences with Dr. Sarah Banks. While at UCSD, Kacie expanded her training to understand racial bias that exists in neuropsychological assessments. While at UCLA, Kacie’s lab will focus is on ethnic and racial disparities in predictors (genetic; neuroimaging; neuropsychological assessments; social/environmental factors) for cognitive decline and Alzheimer’s disease and related dementias in older adults, primarily from the Black community.

Research Interests

Although Black communities are plagued by health disparities, science has continued to center white populations in research. While research into ethnic and racial disparities studies has identified a number of population differences for disease risk factors, it is also important to understand within group heterogeneity in order to elucidate mechanisms underlying cognitive decline. Understanding the intersection of risk factors that drive cognitive decline and dementia in the Black population is critical to accurately assess, predict, and develop interventions for cognitive health. Thus, my goal is understanding the intersection and contributions of genetics and social/environmental factors to cognitive decline and AD. Research will utilize a number of techniques including genetic, neuroimaging, neuropsychological assessments, social and environmental factors, and fluid based biomarkers.

Education

B.S., Biology, University of Alabama, Birmingham 2008
M.S., Biology, California State University, Dominguez Hills 2012
Ph.D., Medical Neuroscience at the Indiana University School of Medicine 2017

Selected Publications

Deters KD, Napolioni V, Sperling RA, Greicius MD, Mayeux R, Hohman T, and Mormino EC. Amyloid PET imaging in self-identified non-Hispanic Blacks from the Anti-Amyloid in Asymptomatic Alzheimer’s Disease (A4) Study. Neurology. 2021. DOI: 10.1212/WNL.0000000000011599. Highlighted with an editorial.

Deters KD, Mormino EC, Yu L, Lutz M, Bennett DA, and Barnes LL. TOMM40-APOE haplotypes are associated with cognitive decline in non-demented Blacks. Alzheimer’s & Dementia. 2021. https://doi.org/10.1002/alz.12295

Avila JF, Rentería MA, Jones RN, Vonk JM, Turney I, Sol K, Nika Seblova N, Arias F, Hill-Jarrett T, Levy SA, Meyer O, Racine AM, Tom SE, Melrose RJ, Deters K, Medina LD, Carrión CI, Díaz-Santos M, Byrd DR, Chesebro A, Colon J, Igwe KC, Maas B, Brickman AM, Schupf N, Mayeux R, and Jennifer Manly J. Education Differentially Contributes to Cognitive Reserve Across Racial/Ethnic Groups. Alzheimer’s & Dementia. 2020. https://doi.org/10.1002/alz.12176

Winer JR, Deters KD, Kennedy G, Jin M, Goldstein-Piekarski A, Poston KL, Mormino EC. Short and long sleep duration are associated with distinct aging pathways. JAMA Neurol. 2021 Aug 30; doi: 10.1001/jamaneurol.2021.2876.

October 2, 2020

Pearl Quijada

Pearl Quijada

Assistant Professor

Email: pquijada@ucla.edu
Office: 1013D TLSB
Phone: (310) 825-2099

Biography

Pearl received her BS in Biology from UC Riverside. To further explore interests in research and medicine, she pursued a Master’s degree in Cell and Molecular Biology at San Diego State University (SDSU) where she also served as a Human Anatomy Teaching Assistant for 3 years. At SDSU, she gained research technical expertise in cardiac pathophysiology and the development of cellular therapies to treat cardiac ischemic injury in the lab of Dr. Mark Sussman. After receiving her PhD from SDSU and UCSD, she began a postdoctoral fellowship under the mentorship of Dr. Eric Small at the University of Rochester where she studied novel mechanisms of epicardium-directed coronary vasculature formation during cardiac development and disease. Continuing her passion for teaching, she was awarded an Outstanding Postdoctoral Mentor Award during her postgraduate training. Transitioning to UCLA and returning to her family, community, and home in Los Angeles – her research lab will focus on evaluating novel cellular and paracrine signaling programs that stimulate angiogenesis in cardiac development, discoveries which may be used to promote cardiac remodeling and repair in the heart after myocardial infarction.

Research Interests

The epicardium is composed of a single cell layer that encapsulates the heart during embryogenesis. The epicardium also serves as a rich source of mesenchymal cells and growth factors that support both cardiomyocyte and coronary vasculature development. Although the function of the epicardium is invariably linked to the growth of the primitive coronary plexus, the cellular and molecular mechanisms that regulate cell autonomous and cell non-autonomous functions of the epicardium remain unclear. To facilitate the identification of the epicardium’s role in embryonic angiogenesis, our lab utilizes transgenic mouse models and single-cell transcriptomic sequencing to discover novel epicardium-directed guidance cues required for arterio-venous specification and maturation. As compared to the fetal heart, the adult myocardium is unable to undergo angiogenesis in response to ischemic injury, which ultimately leads to cardiac functional decline. By using information acquired from our studies during development, we are investigating the effects of secreted factors from the epicardium to promote angiogenesis and repair after ischemic injury in the adult heart.

Education

B.S., University of California, Riverside 2006
M.S., San Diego State University 2010
Ph.D., San Diego State University and University of California, San Diego 2015

Selected Publications

Quijada, P., Trembley, M.A., Small, E.M. The Role of Epicardium During Heart Development and Repair. Circ Res. Jan 31;126(3):377-394 (2020).

 

Quijada, P., Misra, A., Velasquez, L.S., Burke, R.M., Lighthouse, J.K., Mickelsen, D.M., Dirkx, R.A. Jr., Small, E.M. Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging. J Mol Cell Cardiol. 129:92-104 (2019).

 

Quijada, P., Salunga, H.T., Hariharan, N., Cubillo, J., El-Sayed, F., Moshref, M., Bala, K.M., Emathinger, J., De La Torre, A., Ormachea, L., Alvarez, R., Gude, N.A., Sussman, M.A. (2015) Cardiac stem cell hybrids enhance myocardial repair. Circ Res. 117(8):695-706 (2015).

 

Quijada, P., Hariharan, N., Cubillo,J., Bala, K.M., Ormachea, L., Bers, D.M., Sussman, M.A., Poizat, C. Nuclear Calcium/Calmodulin-Dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment. J Biol Chem. 290(42):25411-26 (2015).

 

Quijada, P., Toko, H., Fischer, K.M., Bailey, B., Reilly, P., Hunt, K.D., Gude, N.A., Avitabile, D., Sussman, M.A. Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells. Circ Res. 111(1):77-86 (2012).

April 23, 2020

Stephanie Correa

Stephanie Correa

Associate Professor

Email: stephaniecorrea@ucla.edu
Office: 2028 TLSB
Phone: (310) 825-1559
Website: http://www.correalab.org/

Biography

Stephanie Correa earned a BA in Biology from Pomona College and a PhD in Neurobiology and Behavior from Cornell University. Her dissertation research with Elizabeth Adkins-Regan and Patricia Johnson tested the effects of ovarian steroids on sex determination in birds. Her postdoctoral research at Boston University Medical Center identified strain differences in the testis determination pathway in mice. Postdoctoral research with Holly Ingraham at UCSF identified neurons in the hypothalamus that regulate physical activity and body weight in female mice. Research in her lab aims to understand sex differences in the regulation of temperature and energy balance. Before having twin daughters in 2016, Dr. Correa used to enjoy yoga and sleep.

Research Interests

The Correa lab is broadly interested in understanding how reproductive hormones affect temperature and energy balance. In women, the menopausal transition is associated with hot flashes and increased visceral body fat. Our research aims to understand how estrogens act on the hypothalamus to alter temperature homeostasis and metabolic health. These studies can help us better understand weight gain and hot flashes in postmenopausal women. To understand the mechanisms by which estrogen alters the homeostasis, we focus on the following broad questions: How does the brain regulate temperature and energy balance? How do homeostatic neural circuits differ between males and females? How are homeostatic circuits modulated by estrogens? We use genetically engineered mice and new viral tools to define the neurons that drive estrogen-responsive and sex-specific changes in energy balance. This approach allows us to dissect the effects of estrogen on distinct neuronal populations with spatial, molecular, and temporal specificity. Ultimately, we hope to identify avenues for developing targeted, non-hormonal treatments for hot flashes and obesity.

Education

B.A., Biology, Pomona College 2000
Ph.D., Neurobiology and Behavior, Cornell University 2007

Selected Publications

van Veen, J. E.*, Kammel, L. G.*, Bunda, P. C., Shum, M., Reid, M. S., Massa, M. G., Arneson, D. V., Park, J. W., Zhang, Z., Joseph, A. M., Hrncir, H., Liesa, M., Arnold, A. P., Yang, X., and Correa, S. M. Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure. Nature Metabolism, 2: 351–363 (2020).

Kammel, L. G. and Correa, S. M. Selective sexual differentiation of neuron populations may contribute to sex-specific outputs of the ventromedial hypothalamus. Journal of Neuroendocrinology, 32: e12801 (2020).

Herber C. B.*, Krause, W. C.*, Wang, L., Bayrer, J. R., Li, A., Schmitz, M., Fields, A., Ford, B., Zhang, Z., Reid, M. S., Nomura, D. K., Nissenson, R. A., Correa S. M.#, and Ingraham, H. A.# Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nature Communications, 10: 163 (2019).

Correa, S. M., Newstrom, D. W., Warne J. P., Flandin, P., Cheung, C. C., Pierce, A. A., Lin-Moore, A. T., Xu, A. W., Rubenstein, J. L. and H. A. Ingraham, An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females, Cell Reports, 10 : 62-74 (2015).

Correa, S. M., Washburn, L. L., Kahlon, R. S., Musson, M. C., Bouma, G. J., Eicher, E. M. and Albrecht, K. H., Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway, PLoS Genetics, 8 (4): 1002569-1002588 (2012).

Correa, S. M.#, Horan, C. M., Johnson, P. A., Adkins-Regan, E., Copulatory Behaviors and Body Condition Predict Post-Mating Female Hormone Levels, Fertilization Success, and Primary Sex Ratios in Japanese Quail, Hormones and Behavior, 59 : 556-564 (2011).

Correa, S. M.#, Adkins-Regan, E., and Johnson, P. A., High Progesterone During Avian Meiosis Biases Sex Ratios Toward Females, Biology Letters, 1 : 215-218 (2005).

 

December 13, 2019

Xia Yang

Xia Yang

Professor
Vice Chair, Molecular, Cellular and Integrative Physiology (MCIP) Interdepartmental Ph.D. Program and Computational and Systems Biology (CaSB) Interdepartmental Program

Email: xyang123@ucla.edu
Office: 2000C TLSB
Phone: (310) 206-1812
Website: https://yanglab.ibp.ucla.edu

Biography

Dr. Xia Yang received her Ph.D. in Molecular Genetics and Bioinformatics from Georgia State University and had postdoctoral training in Systems Genetics at UCLA. She was Senior Research Scientist at Rosetta Inpharmatics/Merck & Co. and Director of Systems Biology at Sage Bionetworks prior to returning to UCLA as a faculty member.

Research Interests

Our research focuses on developing and applying multitissue multiomics systems biology approaches to dissect the molecular networks underlying diverse complex diseases, ranging from cardiometabolic diseases to neurodegenerative and neurological disorders, and utilize the systems level networks to guide precision medicine. Through integration of genetic, transcriptional, epigenomic, proteomic, gut microbiota, and phenotypic data from human and rodent populations, we investigate how complex interactions between genetic and environmental risk factors perturb tissue- and cell-specific gene networks which in turn induce variations in disease susceptibility. Subsequently, we use the causal molecular networks of diseases as the basis for therapeutic target identification and biomarker discovery.

Education

B.S., Pharmacy, Shandong University 1993
Ph.D., Molecular Genetics/Bioinformatics, Georgia State University 2003

Selected Publications

Yang X. “Multi-tissue Multi-omics Systems Biology to Dissect Complex Diseases”. Trends in Molecular Medicine, 2020.

Liu W, Venugopal S, Majid S, Ahn IS, Diamante G, Hong J, Yang X*, Chandler SH*. “Single-cell RNA-seq Analysis of the Brainstem of Mutant SOD1 mice Reveals Perturbed Cell Types and Pathways of Amyotrophic Lateral Sclerosis”. Neurobiology of Disease, 141: 104877, 2020.

Rajbhandari P+, Arneson D+, Feng AC, Ahn IS, Diamante G, Zaghari N, Thomas BJ, Vergnes L, Lee SD, Reue K, Smale ST, Yang X, Tontonoz P. “Single Cell Analysis Reveals Immune Cell-Adipocyte Crosstalk Regulating the Transcription of Thermogenic Adipocytes”. eLife 8:e49501, 2019.

Zhang G, Byun HR, Ying Z, Blencowe M, Zhao Y, Hong J, Shu L, Gomez-Pinilla F, Yang X. “Differential Metabolic and Multi-tissue Transcriptomic Responses to Fructose Consumption among Genetically Diverse Mice”. BBA – Molecular Basis of Disease. 1866: 165569, 2020.

Shu L, Meng Q, Tsai B, Diamante G, Chen Y, Mikhail A, Luk H, Ritz B, Allard P, Yang X, “Prenatal Bisphenol A Exposure in Mice Induces Multi-tissue Multi-omics Disruptions Linking to Cardiometabolic Disorders”, Endocrinology, 160 : 409-429, 2019.

Arneson D, Zhuang Y, Byun HR, Ahn IS, Ying Z, Zhang G, Gomez-Pinilla F, Yang X, “Single Cell Molecular Alterations Reveal Pathogenesis and Targets of Concussive Brain Injury”, Nature Communications, 9 : 3894, 2018.

Emilsson V, llkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Jennings LL, Horman SR, Aspelund T, Shu L, Trifonov V, Gudmundsdottir V, Sigurdsson S, Manolescu A, Zhu J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Smith AV, Orth AP, Gudnason V, “Coregulatory Networks of Human Serum Proteins Link Genetics to Disease”, Science, 361 : 769-773, 2018.

Kurt Z, Barrere-Cain R, LaGuardia J, Mehrabian JM, Pan C, Hui ST, Norheim F, Zhou Z, Hasin Y, Lusis AJ, Yang X, “Tissue-specific Pathways and Networks Underlying Sexual Dimorphism in Non-Alcoholic Fatty Liver Disease”, Biology of Sex Differences, 9 : 46- (2018) .

Krishnan KC, Kurt Z, Barrere-Cain R, Sabir S, Das A, Floyd R, Vergnes L, Zhao Y, Che N, Charugundla S, Qi H, Zhou Z, Meng Y, Pan C, Seldin MM, Norheim F, Hui S, Reue K, Lusis, AJ, Yang X., “Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease”, Cell Systems, 6 : 1-13, 2018.

Shu L, Chen KHK, Zhang G, Huan T, Kurt Z, Zhao Y, Codoni V, Tregouet DA, Yang J, Wilson JG, Luo X, Levy D, Lusis AJ, Liu S, Yang X, “Shared Genetic Regulatory Networks for Cardiovascular Disease and Type 2 Diabetes in Multi-ethnic Populations”, PLOS Genetics, 13 (9): e1007040, 2017.

 

December 13, 2019

Alan Garfinkel

Alan Garfinkel

Professor

Email: agarfinkel@mednet.ucla.edu
Office: 1121 TLSB
Phone: (310) 206-8651

Research Interests

Mathematical modeling of cellular and tissue electrophysiology. Analysis of data from experimental and clinical arrhythmias using techniques of nonlinear dynamics (“chaos theory”). Development of pharmacologic and electrophysiologic interventions to prevent or control arrhythmias.

Education

B.A., Math and Philosophy, Cornell University
Ph.D., Philosophy/Mathematics, Harvard University

December 13, 2019

Alan Grinnell

Alan Grinnell

Distinguished Professor

Email: adg@ucla.edu
Office: 1220 JLNRC
Phone: (310) 825-4468

Biography

PhD Harvard, 1962; Junior Fellow, Harvard, 1959-62; postdoc UCLondon, 1962-64; UCLA faculty, 1964-present, Departments of Physiology (SOM) and Integrative Biology and Physiology IBP (College); Director, Jerry Lewis Neuromuscular Research Center, 1978-2001; Director, Ahmanson Laboratory of Neurobiology, 1979-2004; Chair, IBP Department 1997-2001; Associate Dean of Life Sciences for Personnel, 2010-

Research Interests

Adaptations of the auditory nervous system of echolocating bats that enable them to orient and hunt using echoes of emitted sounds as a substitute for vision. Also, bat echolocation behavior and feeding strategies. Trophic influences between nerve and muscle governing number, size and strength of nerve terminals. Regulation of neurotransmitter release and properties of presynaptic active zones.
Specific Recent Projects: a. Using Xenopus nerve-muscle cell cultures, patch electrode recordings can be made simultaneously from presynaptic varicosities and postsynaptic muscle cells. Large conductance Ca2+-dependent K+ (BK) channels that co-localize with Ca2+ channels at presynaptic active zones (AZs) can be used to report [Ca2+] at AZs and correlate this direct measurement with neurotransmitter release. This allows correlation of ionic currents with transmitter release and modulation of release, and analysis of molecular mechanisms of release. b. Using mature frog neuromuscular preparations, we are studying the mechanisms of regulation of transmitter release efficacy by muscle stretch, mediated by integrins. c. Using an old world flying fox bat that has excellent night vision but also has evolved good echolocation, we are attempting to determine whether they can shift seamlessly from one modality to the other. I also have a long-standing interest in the art and iconography of preColumbian ceramics from Central Panama.

Education

B.A., Biology, Harvard University 1958
Ph.D., Biology, Harvard University 1962

Selected Publications

Grinnell AD. (2018) Early milestones in the study of echolocation in bats. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2018 Jun;204(6):519-536. doi: 10.1007/s00359-018-1263-3. Epub 2018 Apr 23. Review.

Sun XP, Chen BM, Sand O, Kidokoro Y, Grinnell AD. (2010) Depolarization-induced Ca2+ entry evokes release of large quanta in the developing Xenopus neuromuscular junction.J Neurophysiol. 2010 Nov;104(5):2730-40. doi: 10.1152/jn.01041.2009. Epub 2010 Sep 15. PMID: 20844112

Sun XP, Yazejian B, Grinnell AD. (2004) Electrophysiological properties of BK channels in Xenopus motor nerve terminals. J Physiol. 2004 May 15;557(Pt 1):207-28. Epub 2004 Mar 26. PMID: 15047773

Yazejian B, Sun XP, Grinnell AD. (2000) Tracking presynaptic Ca2+ dynamics during neurotransmitter release with Ca2+-activated K+ channels. Nat Neurosci. 2000 Jun;3(6):566-71. PMID: 10816312

Chen BM, Grinnell AD. (1997) Kinetics, Ca2+ dependence and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor nerve terminals. J Neurosci. 1997 Feb 1;17(3):904-16.PMID: 8994045

 

December 13, 2019

Peter Narins

Peter Narins

Distinguished Professor

Email: pnarins@ucla.edu
Office: 4835 LS
Phone: (310) 825-0265

Research Interests

My research focuses on the question of how animals extract relevant sounds from the often highly noisy backgrounds in which they live. The techniques I use are the quantitative analysis of vocal behavior of animals in their natural habitats, followed by single fiber neurophysiological recordings in order to elucidate mechanisms underlying signal processing in noise. A second research direction is based on the discovery of the remarkable sensitivity to substrate vibrations possessed by burrowing animals. We are now characterizing and providing accurate measurements of vibrational thresholds as well as exploring the differences between substrate-vibration and airborne sound at the cellular level. Other projects carried out by our group have included an investigation of the neurophysiological basis of sound localization in noisy environments, a study of the temperature-dependence of the representation of time in the vertebrate auditory system, the biophysics of sound localization and the evolution of the middle ear reflex in vertebrates. Current projects include using laser Doppler vibrometry to elucidate the sound pathways relevant for stimulation of both the middle and inner ear in small vertebrates, and using whole-cell voltage clamp techniques to carry out an anatomical and physiological study of the mechanisms underlying transduction in vertebrate sensory hair cells. In addition, we supplement the lab work with direct behavioral observations and controlled acoustic playback studies carried out with animals in their natural habitats. These have included both Old and New World lowland wet tropical forests, African deserts and temperate forests in South America.

Education

B.S., Electrical Engineering, Cornell University 1965
M.S., Electrical Engineering, Cornell University 1966
Ph.D., Neurobiology and Behavior, Cornell University 1976

Selected Publications

Narins, P.M. and Meenderink, S.W.F., “Climate change and frog calls: Long-term correlations along a tropical altitudinal gradient”, Proc. Roy. Soc. Lond, 281 : 1-6 (2014) .

Narins, P.M., Wilson, M. and Mann, D., “Ultrasound detection in fishes and frogs: Discovery and mechanisms”, In: Insights from Comparative Hearing Research, C. Koeppl, G.A. Manley, A.N. Popper, R.R. Fay(Eds.), 133-156 (2014) .

Adler, K., Narins, P.M. and Ryan, M.J., “Obituary. Robert R. Capranica (1931-2012) and the Science of Anuran Communication”, Herpetological Review, 44 : 554-556 (2013) .

Miller, M.E., Nasiri, A.K., Farhangi, P.O., Farahbakhsh, N.A., Lopez, I.A., Narins, P.M. and Simmons, D.D., “Evidence for water-permeable channels in auditory hair cells in the leopard frog”, Hear. Res, 292 : 64-70 (2012) .

Manley, G.A., Narins, P.M. and Fay, R.R,, “Experiments in comparative hearing: Georg von Bekesy and beyond”, Hear. Res, 293 : 44-50 (2012) .

Cui, J., Tang, Y. and Narins, P.M., “Real estate ads in Emei music frog vocalizations: Female preference for calls emanating from burrows”, Biol. Letters, 8 : 337-340 (2012) .

Chen. H.-H. A. and Narins, P.M., “Wind turbines and ghost stories: The effects of infrasound on the human auditory system”, Acoustics Today, 8 : 51-56 (2012) .

Quinones, P.M., Luu, C., Schweizer, F.E. and Narins, P.M., “Exocytosis in the frog amphibian papilla”, J. Asso. Res. Otolaryngol, 13 : 39-54 (2012) .

Arch, V.S., Simmons, D.D., Quinones, P.M., Feng, A.S., Jiang, J., Stuart, B., Shen, J.-X., Blair, C. and Narins, P.M., “Inner ear morphological correlates of ultrasonic hearing in frogs”, Hear. Res, 283 : 70-79 (2012) .

Shen, J.-X., Xu. Z.-M., Feng, A. and Narins, P.M., “Large odorous frogs (Odorrana graminea) produce ultrasonic calls”, J. Comp. Physiol, 197 : 1027-1030 (2011) .

 

December 13, 2019

Claudio Villanueva

Claudio Villanueva

Associate Professor

Email: cvillanueva@g.ucla.edu
Office: 27-200K CHS
Phone: (310) 825-4369
Website: https://sites.lifesci.ucla.edu/ibp-villanuevalab/

Biography

Professor Villanueva completed his undergraduate training at Cal State San Bernardino where he studied hormonal regulation of sodium uptake across the abdominal epithelium. He was fascinated by the way multicellular organisms’ sense and adapt to the surrounding environment. This early training sparked his interest in Integrative Physiology. As a Ph.D. student at UCSF, he trained at the Gladstone Institute of Cardiovascular Disease, where he studied lipid metabolism. He investigated the role of DGAT enzymes in fatty liver disease. His postdoc training was completed at UCLA, where he studied transcriptional mechanisms that regulate cellular programming of metabolism. He was recruited to the Department of Biochemistry at the University of Utah School of Medicine, and in 2019 joined the Department of Integrative Biology and Physiology at UCLA. His research aims to understand the metabolic adaptations required for cold adaptation in mammals.

Research Interests

Dr. Villanueva is interested in understanding how cells sense and control metabolism in response to stressors like temperature. The ability to maintain a constant body temperature despite a changing environment can lead to dramatic changes in energy expenditure. This requires an understanding of integrative metabolism and physiology. His lab will explore the molecular mechanisms that promote energy expenditure. He wants to understand how adipocytes regulate energy balance and how they communicate with the liver. These studies will provide opportunities for intervening in metabolic diseases that are associated with obesity.

Education

B.A., Biology, California State University, San Bernardino 2001
Ph.D., Lipid Biochemistry, University of California, San Francisco 2007

Selected Publications

Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J. “Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.”
Cell Metab. 31(2):284-300 (2020).

Anthony RP Verkerke, Patrick J Ferrara, Chien-Te Lin, Jordan M Johnson, Terence E Ryan, J Alan Maschek, Hiroaki Eshima, Christopher W Paran, Brenton T Laing, Piyarat Siripoksup, Trevor S Tippetts, Edward J Wentzler, Hu Huang, Espen E Spangenburg, Jeffrey J Brault, Claudio J Villanueva, Scott A Summers, William L Holland, James E Cox, Dennis E Vance, P Darrell Neufer, Katsuhiko Funai., “Phospholipid methylation regulates muscle metabolic rate through Ca 2+ transport. efficiency”, Nature Metabolism, 1 : 876-885 (2019) .

Charisse Petersen, Rickesha Bell, Kendra A Klag, Soh-Hyun Lee, Raymond Soto, Arevik Ghazaryan, Kaitlin Buhrke, H Atakan Ekiz, Kyla S Ost, Sihem Boudina, Ryan M O’Connell, James E Cox, Claudio J Villanueva, W Zac Stephens, June L Round., “T cell-mediated regulation of the microbiota protects against obesity”, Science, 365 (6451): (2019) .

Gisela Geoghegan, Judith Simcox, Marcus M Seldin, Timothy J Parnell, Chris Stubben, Steven Just, Lori Begaye, Aldons J Lusis, Claudio J Villanueva., “Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism”, Molecular Metabolism, 24 : 44-63 (2019).

Stephanie Pearson, Anne Loft, Prashant Rahbhandari, Judith Simcox, Sanghoon Lee, Peter Tontonoz, Susanne Mandrup, Claudio J Villanueva., “Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism”, Genes & Development, (2019).

Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Ruozhen Hu, Jared Wallace, Charisse Petersen, Vanja Panic, Claudio J Villanueva, Kimberley J Evason, Kaylyn M Bauer, Timothy Mosbruger, Sihem Boudina, Mary Bronner, June L Round, Micah J Drummond, Ryan M O’Connell., “Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease”, PLOS Genetics, 15 (2): (2019).

Gilles Storelli, Hyuck-Jin Nam, Judith Simcox, Claudio J Villanueva, Carl S Thummel., “Drosophila HNF4 directs a switch in lipid metabolism that supports the transition to adulthood”, Developmental Cell, 48 (2): 200-214 (2019).

Simon T Bond, Sarah C Moody, Yingying Liu, Mete Civelek, Claudio J Villanueva, Paul Gregorevic, Bronwyn A Kingwell, Andrea L Hevener, Aldons J Lusis, Darren C Henstridge, Anna C Calkin, Brian G Drew., “The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes”, American Journal of Physiology-Endocrinology and Metabolism, 316 (2): E293-E304 (2018).

Santhosh Karanth, JD Adams, Maria de los Angeles Serrano, Ezekiel B Quittner-Strom, Judith Simcox, Claudio J Villanueva, Lale Ozcan, William L Holland, H Joseph Yost, Adrian Vella, Amnon Schlegel., “A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose”, Cell Reports, 24 (2): 312-319 (2018).

Judith Simcox, Gisela Geoghegan, John Alan Maschek, Claire L Bensard, Marzia Pasquali, Ren Miao, Sanghoon Lee, Lei Jiang, Ian Huck, Erin E Kershaw, Anthony J Donato, Udayan Apte, Nicola Longo, Jared Rutter, Renate Schreiber, Rudolf Zechner, James Cox, Claudio J Villanueva, “Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis”, Cell Metabolism, 26 (3): 509-522 (2017) .

 

December 13, 2019

David Walker

David Walker

Professor
Vice Chair of Academic Personnel

Email: davidwalker@ucla.edu
Office: 2018 TLSB
Phone: (310) 825-7179

Biography

I completed my undergraduate degree in Genetics at Queen’s University of Belfast, Northern Ireland. I then went on to complete both Master’s and Ph.D. degrees at the University of Manchester, UK. I carried out postdoctoral work at the California Institute of Technology (Caltech), where I received training in Drosophila genetics in the laboratory of Seymour Benzer and training in mitochondrial biology in the laboratory of Giuseppe Attardi. I established my independent research group at UCLA in 2007.

Research Interests

The mechanisms that cause the deterioration of cellular functions during the aging process remain poorly understood. Our lab is using the powerful genetics of the fruit fly Drosophila melanogaster to better understand the molecular and cellular mechanisms of aging. Drosophila has proven to be an invaluable resource for understanding many molecular and cellular mechanisms of human disease, powered by versatile gene discovery methods and a biology that has much in common with that of humans. The long-term aim of this research is to provide novel therapeutic targets to counteract age-related human diseases.

Education

B.S., Genetics, Queen’s University Belfast 1995
MRes, Molecular Biology, University of Manchester 1996
Ph.D., Genetics, University of Manchester 2000

Selected Publications

Schmid, E.T., Pyo, JH. & Walker, D.W. Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila. Nature Aging 2, 494–507 (2022). 

Aparicio, R., Schmid, E.T. & Walker, D.W. Gut mitochondrial defects drive neurodegeneration. Nature Aging 2, 277–279 (2022).

Aparicio, R., Rana, A., Walker, D.W., “Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila”, Cell Reports, 28 : 1029-1040 (2019).

Schinaman, J.S., Rana, A., Ja, W.W., Clark, R.I., & Walker, D.W., “Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila”, Scientific Reports, 9 (1): 7824- (2019).

Salazar A.M., Resnik-Docampo M., Ulgherait, M., Clark R.I., Shirasu-Hiza M., Jones, D.L., Walker, D.W., “Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity”, iScience, 9 : 229-243 (2018).

Hansen M., Rubinsztein, D.C., Walker, D.W., “Autophagy as a promoter of longevity: insights from model organisms”, Nature Rev Mol Cell Biol, 19 (9): 579-593 (2018).

Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, Walker DW, ” Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster”, Nature Communications, 8 (1): 448- (2017).

Resnik-Docampo M, Koehler CL, Clark RI, Schinaman JM, Sauer V, Wong DM, Lewis S, D’Alterio C, Walker DW, Jones DL, “Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis”, Nature Cell Biology, 19 (1): 52-59 (2017).

Clark RI, Salazar A, Yamada R, Fitz-Gibbon S, Morselli M, Alcaraz J, Rana A, Rera M, Pellegrini M, Ja WW, Walker DW., “Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality”, Cell Reports, 12 (10): 1656-1667 (2015) . Ulgherait M., Rana A., Rera M., Graniel J., Walker D.W., “AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner”, Cell Reports, 8 (6): 1767-1780 (2014).

Rana A, Rera M, Walker D.W., “Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan”, Proc Natl Acad Sci USA, 110 : 8638-8643 (2013).

Rera, M, Clark, R.I., Walker D.W., “Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila”, Proc Natl Acad Sci USA, 109 (52): 21528-21533 (2012).